Jesse Hudspeth was born and raised in Arvada, Colorado. He received his bachelor of science in chemistry with a concentration in biochemistry and a minor in philosophy from The University of Alabama, Tuscaloosa (roll tide!) in December 2019. During his undergraduate studies, he worked under the direction of Dr. Martin G. Bakker to determine the critical micelle concentration of the surfactant Pluronic F127 in structural synthesis. He also worked on synthesizing various organometallic phthalocyanine complexes to act as catalytic frameworks in mesoporous carbon monoliths. In August 2020, he began his PhD in applied chemistry under the direction of Dr. Christine N. Morrison at the Colorado School of Mines, where he is investigating bacterial cysteine desulfurases as potential targets for novel antibacterial therapeutics to combat the antibiotic resistance crisis. For the 2022–23 Fulbright program year, he is working under the direction of Dr. Bernhard Rupp at the Medical University of Innsbruck with the assistance of Dr. Dirk Hoffmeister at the Leibniz Institute for Natural Products Research and Infection Biology to structurally characterize the phosphatidylserine decarboxylase responsible for the fist step in the biosynthesis of psilocybin in magic mushrooms, PsiD.